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951
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=C(/C=C/c1ccccc1)/C=C/c1ccccc1" }
{ "index": 0, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
O=C(/C=C/c1ccccc1)/C=C/c1ccccc1
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "C.C.[Al+].[CH3-].[Cl-].[Ti+3].c1cc[cH-]c1.c1cc[cH-]c1" }
{ "index": 1, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
C.C.[Al+].[CH3-].[Cl-].[Ti+3].c1cc[cH-]c1.c1cc[cH-]c1
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CC(C)C[AlH]CC(C)C" }
{ "index": 2, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
CC(C)C[AlH]CC(C)C
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CC(C)(O)C(O)=Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1" }
{ "index": 3, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
CC(C)(O)C(O)=Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "[AlH4-].[Na+]" }
{ "index": 4, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
[AlH4-].[Na+]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "Clc1cccc(Cl)c1" }
{ "index": 5, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
Clc1cccc(Cl)c1
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(/C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2" }
{ "index": 6, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(/C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C\\C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\\C=C\\[C@@H]3C)[C@]54O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O" }
{ "index": 7, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C\C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@]54O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[Al+3].[NH4+]" }
{ "index": 8, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[Al+3].[NH4+]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "F[Al-3](F)(F)(F)(F)F.[Na+].[Na+].[Na+]" }
{ "index": 9, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describe...
tool_agent
F[Al-3](F)(F)(F)(F)F.[Na+].[Na+].[Na+]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "[35SH2]" }
{ "index": 10, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
[35SH2]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "C[Al](C)C" }
{ "index": 11, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
C[Al](C)C
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=[Al][O-].[Li+]" }
{ "index": 12, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
O=[Al][O-].[Li+]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=[Al][O-].[Na+]" }
{ "index": 13, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
O=[Al][O-].[Na+]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "[Al]#[Ta]" }
{ "index": 14, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
[Al]#[Ta]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=S(=O)(O)O" }
{ "index": 15, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
O=S(=O)(O)O
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=[Al][O-].O=[Al][O-].[Mg+2]" }
{ "index": 16, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
O=[Al][O-].O=[Al][O-].[Mg+2]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=C(O)CCC(=O)CC(=O)CC(=O)O" }
{ "index": 17, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
O=C(O)CCC(=O)CC(=O)CC(=O)O
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "[Al]#[Ti]" }
{ "index": 18, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
[Al]#[Ti]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=CCCC(=O)O" }
{ "index": 19, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
O=CCCC(=O)O
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CC(=O)N" }
{ "index": 20, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CC(=O)N
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=C1C=CC(=O)C(CC(=O)O)=C1" }
{ "index": 21, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
O=C1C=CC(=O)C(CC(=O)O)=C1
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CC[Al](Cl)Cl" }
{ "index": 22, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CC[Al](Cl)Cl
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "[Al+3].[Cl-].[Cl-].[Cl-].[Cl-].[Li+]" }
{ "index": 23, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
[Al+3].[Cl-].[Cl-].[Cl-].[Cl-].[Li+]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[Al+3].[Na+]" }
{ "index": 24, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[Al+3].[Na+]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C5C=COC5OC4=C1" }
{ "index": 25, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C5C=COC5OC4=C1
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CC(=O)NC(CS)C(=O)O" }
{ "index": 26, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CC(=O)NC(CS)C(=O)O
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "C1C2C=CC1C3C2C4(C(=C(C3(C4(Cl)Cl)Cl)Cl)Cl)Cl" }
{ "index": 27, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
C1C2C=CC1C3C2C4(C(=C(C3(C4(Cl)Cl)Cl)Cl)Cl)Cl
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "[O-2].[O-2].[O-2].[As+3].[As+3]" }
{ "index": 28, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
[O-2].[O-2].[O-2].[As+3].[As+3]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CC(C)C[Al](CC(C)C)CC(C)C" }
{ "index": 29, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CC(C)C[Al](CC(C)C)CC(C)C
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CCCCCCCCCCCCCCCC(=O)O[Al](OC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC" }
{ "index": 30, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CCCCCCCCCCCCCCCC(=O)O[Al](OC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CC[Al](Cl)CC" }
{ "index": 31, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CC[Al](Cl)CC
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "[O-][As]=O.[Na+]" }
{ "index": 32, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
[O-][As]=O.[Na+]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CCO[Al](OCC)OCC" }
{ "index": 33, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CCO[Al](OCC)OCC
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "C(C(C1C(=C(C(=O)O1)O)O)O)O" }
{ "index": 34, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
C(C(C1C(=C(C(=O)O1)O)O)O)O
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "C1=CC=C(C=C1)CCl" }
{ "index": 35, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
C1=CC=C(C=C1)CCl
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "C1=CC=C(C=C1)N" }
{ "index": 36, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
C1=CC=C(C=C1)N
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CCCCCCCCCCCCCCCCCC(=O)O[Al]OC(=O)CCCCCCCCCCCCCCCCC.O" }
{ "index": 37, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CCCCCCCCCCCCCCCCCC(=O)O[Al]OC(=O)CCCCCCCCCCCCCCCCC.O
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Al+3]" }
{ "index": 38, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Al+3]
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CCCC[Al](CCCC)CCCC" }
{ "index": 39, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CCCC[Al](CCCC)CCCC
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CC1=C(C=CC=C1C2=CC=CC=C2)COC(=O)C3C(C3(C)C)C=C(C(F)(F)F)Cl" }
{ "index": 40, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CC1=C(C=CC=C1C2=CC=CC=C2)COC(=O)C3C(C3(C)C)C=C(C(F)(F)F)Cl
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CCCCCCCC[Al](CCCCCCCC)CCCCCCCC" }
{ "index": 41, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CCCCCCCC[Al](CCCCCCCC)CCCCCCCC
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CCCCCCCCCCCC[Al](CCCCCCCCCCCC)CCCCCCCCCCCC" }
{ "index": 42, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CCCCCCCCCCCC[Al](CCCCCCCCCCCC)CCCCCCCCCCCC
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "C1C2C(C(C1Cl)Cl)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl" }
{ "index": 43, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
C1C2C(C(C1Cl)Cl)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "C1=CC=C2C(=C1)C3=CC=CC=C3N2" }
{ "index": 44, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
C1=CC=C2C(=C1)C3=CC=CC=C3N2
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CCCCCCCCCC[Al](CCCCCCCCCC)CCCCCCCCCC" }
{ "index": 45, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CCCCCCCCCC[Al](CCCCCCCCCC)CCCCCCCCCC
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "CCCCCCCCCCCCCC[Al](CCCCCCCCCCCCCC)CCCCCCCCCCCCCC" }
{ "index": 46, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
CCCCCCCCCCCCCC[Al](CCCCCCCCCCCCCC)CCCCCCCCCCCCCC
[ { "content": "Please analyze the following molecule and propose a repaired molecule.\n\nYour goal is to find the best verified molecule that is feasible, \nsafer than the original molecule, and structurally similar to it.\n\nWhen calling a tool, the content inside <tool_call>...</tool_call> \nmust be a valid JS...
[ { "function": { "description": "Predict molecule safety score from SMILES.", "name": "predict_toxicity", "parameters": { "additionalProperties": false, "properties": { "candidate_smiles": null, "endpoint": { "description": "Optional toxicity endp...
tox_rl_train
{ "ground_truth": "C1=CC=C(C=C1)CC2=C(C=CC(=C2)Cl)O" }
{ "index": 47, "input": "Please analyze the toxicity of the following molecule and propose a repaired molecule. Reason step by step, and you may use tools to assist your reasoning.\n\nAt the end, provide the final answer in the following format:\n<desc>...</desc>\n<repair>...</repair>\n\nHere, <desc> should describ...
tool_agent
C1=CC=C(C=C1)CC2=C(C=CC(=C2)Cl)O
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